The Holy House of Mercy of Macau, is a historic white building in Senado Square, Macau, China. Established as a branch of the Santa Casa da Misericórdia, it was built in 1569 on the orders of the Bishop of Macao.
It was a medical clinic and several other social welfare structures in early Macau. It later served as an orphanage and refuge for widows of sailors lost at sea.
It is part of the UNESCO World Heritage Site "Historic Centre of Macau".
The Museum of Holy House of Mercy was opened in 2001. It contains items of donated sacrificial offerings including a portrait of Sacred Heart of Jesus, ivory sculpture of Madonna, a sculpture of Jesus on the Cross and some porcelain. The most eye-catching and precious relic in the Museum of Holy House of Mercy is a manual script of Regulations of Macau’s Holy House of Mercy which was written in 1662. Other noted items include the skull of its founder, D. Belchior Carneiro, a funerary cross.